James T Kirks semester på Jorden avbryts av att Enterprise får ett viktigt uppdrag till fredsplaneten Nimbus III där ett antal viktiga federationspersonal hålls fången av en skurk vid namn Sybok. Kirks försöka att frita gisslan misslyckas och detta leder istället till att Sybok intar Enterprise och beordrar rymdskeppet att resa till det farliga området nära galaxens centrum där Sybok hoppas finna gud.
År: 2287 (september)
Astronomi: Nimbus III
Skepp och stationer: Enterprise NCC-1701-A
Spock: "I do not believe you realize the gravity of your situation."
Kirk: "Gravity was foremost on my mind."
Kirk: "Damn it, Bones, you're a doctor. You know that pain and guilt can't be taken away with a wave of a magic wand. They're the things we carry with us, the things that make us who we are. If we lose them, we lose ourselves. I don't want my pain taken away! I need my pain!"
Kirk: "Excuse me... Excuse me... I just wanted to ask a question. What does God need with a starship?"
Sybok: "Spock. It's me. It's Sybok. After all these years you've finally caught up with me. Don't you have anything to say to me?"
Spock: "You are... under arrest. For seventeen violations of the Neutral Zone Treaty."
St. John Talbot: "And tell me, Miss Dar, how did you end up stuck here, in the armpit of the galaxy?"
Caithlin Dar: "I volunteered."
St. John Talbot: "Volunteered?"
Sulu: "I still think I should have gone to Yosemite with the Captain."
Chekov: "What's the difference? You've seen one national park, you've seen them all."
Kirk: "Mr. Scott, you're a miracle!"
Scotty: "There's no miracle about it. I know this ship like the back of my hand." (går in i en balk och svimmar)